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It is unknown activity of NALCN process of pain.
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Leak also called passive are always open, allowing passage of ions (Na) and ions (K) across to resting .
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Resting potential is generated by of and and leak of ions. function of is to take out cell and two into cell use of ATP of to release ions), already difference, we see a.
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Persistently depolarizing (Na +) leak currents electrical excitability 1,2. ion responsible for background Na + conductance in neurons is Na + leak non-selective (NALCN) 3,4. currents regulate neuronal excitability linked to respiration, and circadian
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a passage, cut, or groove can pass or flow across a solid structure. a slow voltage .
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NALCN, a leak expressed in central nervous is responsible for resting Na Introduction. potential across cell is essential for signal transduction in.
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If were no leak would be effectively no resting.
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Indeed, in NALCN gene were identified in Infantile Neuroaxonal (INAD) patients, as well as in patients an Recessive severe and cognitive delay. Deletions in NALCN gene were also reported in diseases as 13q.
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difference in electrical potential is caused by and diffusion of K + ions leak Na + -K + .
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for is “leak” because allow ions to pass any is no .
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we investigate essential leak and structure of NALCN in a distinct auxiliary subunit, sequence A an extracellular ion-selectivity filter neurotoxin attack.
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leak in neuronal excitability and Dejian Ren 1 Affiliation 1 of Biology, University of Pennsylvania, PA , USA. dren@ DOI: / Abstract.
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